https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18338 Wed 24 Jun 2015 11:36:33 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22033 Wed 11 Apr 2018 13:40:02 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38703 Wed 06 Jul 2022 10:42:43 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23095 Thu 28 Oct 2021 12:36:41 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52638 Thu 19 Oct 2023 15:12:05 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7969 Sat 24 Mar 2018 08:33:40 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15325 Sat 24 Mar 2018 08:26:35 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21715 Sat 24 Mar 2018 08:06:26 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17430 2 s was the most accurate computed tomography perfusion threshold in predicting the extent of critically hypoperfused tissue with both receiver operating curve analysis (area under curve 0.86), and the volumetric validation (mean difference between computed tomography perfusion and 24-h diffusion-weighted imaging lesions = 2 cm², 95% confidence interval 0.5–3.2 cm²). Cerebral blood flow <40% (of contralateral) within the relative delay time >2 s perfusion lesion was the most accurate computed tomography perfusion threshold at defining infarct core with both receiver operating characteristic analysis (area under curve = 0.85) and the volumetric validation. Using these thresholds, the extent of computed tomography perfusion mismatch tissue (the volume of ‘at-risk’ tissue between the critically hypoperfused and core thresholds) salvaged from infarction correlated with clinical improvement at 24 h (R² = 0.59, P = 0.04) and 90 days (R² = 0.42, P = 0.02). Patients with larger baseline computed tomography perfusion infarct core volume (>25 ml) also had poorer recovery at Day 90 (P = 0.039). Computed tomography perfusion can accurately identify critically hypoperfused tissue that progresses to infarction without early reperfusion, and the computed tomography perfusion cerebral blood flow infarct core closely predicts the final volume of infarcted tissue in patients who do reperfuse. The computed tomography perfusion infarct core and at-risk measures identified are also strong predictors of clinical outcome.]]> Sat 24 Mar 2018 08:01:40 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18959 Sat 24 Mar 2018 07:58:54 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19935 Sat 24 Mar 2018 07:58:30 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17780 1.2 and total coregistered mismatch volume was ≥10 mL. The primary outcome was a comparison of infarct growth in alteplase vs placebo patients with coregistered mismatch. Of 99 patients with baseline diffusion-weighted imaging and perfusion-weighted imaging, coregistration of both images was possible in 95 patients. Coregistered mismatch was present in 93% (88/95) compared to 85% (81/95) with standard volumetric mismatch. In the coregistered mismatch patients, of whom 45 received alteplase and 43 received placebo, the primary outcome measure of geometric mean infarct growth was significantly attenuated by a ratio of 0.58 with alteplase compared to placebo (1.02 vs 1.77; 95% CI, 0.33–0.99; P=0.0459). When using coregistration techniques to determine the presence of mismatch at study entry, alteplase significantly attenuated infarct growth. This highlights the necessity for a randomized, placebo-controlled, phase III clinical trial of alteplase using penumbral selection beyond 3 hours.]]> Sat 24 Mar 2018 07:57:41 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19818 Sat 24 Mar 2018 07:56:57 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:117 Sat 24 Mar 2018 07:43:16 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22635 Sat 24 Mar 2018 07:11:27 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22101 Fri 16 Aug 2024 16:04:01 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35602 Fri 13 Sep 2019 15:57:13 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44114 Fri 07 Oct 2022 14:05:24 AEDT ]]>